4. Clinical Virology

Group Members 

Helmut Fickenscher, Prof. Dr. med.
fickenscher@infmed.uni-kiel.de
phone: +49-431/597-3300, fax: +49-431-597-2216
Christina Heuer, Secretary
krueger@infmed.uni-kiel.de
phone: +49-431/597-3301
Anne Brunnemann, Dipl. Biol.
brunnemann@infmed.uni-kiel.de
phone: +49-431/597-4284
Linda Bremerhueske@infmed.uni-kiel.de
phone: +49-431/597-4282
Michael Klages, Cand. med.
klages@infmed.uni-kiel.de
phone: +49-431/597-4281
Tanja Krater, Dipl. Biol.
krater@infmed.uni-kiel.de
phone: +49-431/597-3312
Gabi Prühs-Havemann, Technician (MTLA)
pruehs@infmed.uni-kiel.de
phone: +49-431/597-3304

Previous members of the group

Christian Bökel, Dr. rer. nat.
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
boekel@mpi-cbg.de
Stefanie Heinemann, Dr. rer. nat.
Antikörper-Firma
neue email
Christian Hiller, Dr. rer. nat.
Noris… Neumarkt
neue email
Simon Hör, Dr. rer. nat.
neue Adresse in Wien?
neue email
Sabrina Hoffmann, Dr. rer. nat.
neue Adresse
neue email
Andrea Knappe, Dr. rer. nat.
Bavarian Nordic Research Institute, Martinsried
knappe@bavarian-nordic.de
Mirko Kummer, Dr. rer. nat.
Dermatologische Universitätsklinik, Erlangen
mirko.kummer@derma.imed.uni-erlangen.de
Heide Pirzer, Dr. rer. nat., Mannheim
Dorothee Preimel, Dr. rer. nat.
neue Firma
neue email
Michaela Schmidt, Dr. rer. nat.
Bavarian Nordic Research Institute, Martinsried
michaela.schmidt@bavarian-nordic.com
Miriam Svorcova, Dr. rer. nat.
neue Adresse
neue email
Gültekin Tamgüney, Prof. Dr. rer. nat.
Institute for Neurodegenerative Diseases, University of California San Francisco
etamguney@itsa.ucsf.edu
Mathias Thurau, Dr. rer. nat., Erlangen
Niels Weinhold, Dipl. Biol.
Clinic for Hematology and Onkology, University Medical Center Heidelberg
niels.weinhold@med.uni-heidelberg.de
Elisabeth Schneider, Dr. med., Karlsruhe
Tuna Toptan, Dr. med., MD, physician
University of Pittsburgh, Tumor Virus Laboratory
tut@... neue email
Felix Wussow, Dr. rer. nat.
City of Hope Comprehensive Cancer Center and Translational Vaccine Center, Beckman Research Institute, Duarte, California
neue email

Curriculum vitae

2005
Chair of Virology, Christian-Abrecht University of Kiel, Director of the Institute of Infection Medicine and Head of the Central Unit for Hospital and Environmental Hygiene, University Medical Center Schleswig-Holstein Campus Kiel.
2002
Associate Professor of Clinical Virology, Ruprecht-Karls-Universität Heidelberg.

2001
Medical specialization in Microbiology und Epidemiology of Infection.
Research award of the Varicella Zoster Virus Research Foundation, New York.
1998
Habilitation, Privatdozent (University of Erlangen-Nuremberg).

1991-2001
Principal investigator at the Institute for Clinial and Molecular Virology, University of Erlangen-Nuremberg.

1989-1991
Research fellow at the Max Planck Institute for Biophysical Chemistry at Göttingen
(with Prof. Dr. Peter Gruss): Mouse developmental control genes.

1989
Dr. med., thesis on transcription regulation in human cytomegalovirus
(with Prof. Dr. Bernhard Fleckenstein, University of Erlangen-Nuremberg).

1988
Graduation from Medical School (University of Erlangen-Nuremberg). Medical License.

 

Additional academic, scientific and medical functions

Academisch
Sektion Biologie, Mathematisch-Naturwissenschaftliche Fakultät, Kooptiertes Mitglied
Fachbereichsrat, Medizinische Fakultät der CAU Kiel, gewählter Stellvertreter
Senat der CAU Kiel, gewähltes Mitglied
Kommission für Wissenschaftlichen und Künstlerischen Nachwuchs, CAU Kiel, Member
Wissenschaftlich
Gesellschaft für Virologie (GfV), Beiratsmitglied
Gesellschaft für Virologie (GfV), Kommission für Lehre, Fort- und Weiterbildung, Vorsitzender
Gesellschaft für Virologie (GfV), Kommission für Akademische Belange und Internationale Beziehungen, Mitglied
Gesellschaft für Virologie (GfV), Kommission für Virussicherheit, Mitglied
Deutsche Gesellschaft für Hygiene und Mikrobiologie (DGHM), Vorstandsmitglied
Kommission für Biologische Gefahren, Bundesinstitut für Risikobewertung, Berlin, Mitglied
Expertenkommission für Biologie und Anatomie, Institut für Medizinische und Pharmazeutische Prüfungsfragen (IMPP), Mitglied
Medical
Medizinisches Versorgungszentrum Kiel der Ambulanzzentrum des UKSH gGmH, Ärztlicher Leiter
Standort-übergreifendes Zentrum Interdisziplinäre Fächer, UKSH, Ärztlicher Leiter (2008-2009)
Berufsverband der Ärztinnen und Ärzte für Mikrobiologie, Virologie und Infektionsepidemiologie (BÄMI e.V.), Stellvertretender Bundesvoristzender und Landesobmann Schleswig-Holstein
Deutsche Akkreditierungsstelle (DAkkS), Gutachter

Funding since 2005

Deutsche Forschungsgemeinschaft, Sonderforschungsbereich 617 "Mechanismen epithelialer Abwehr", Teilprojekt A24
Focus Clinical Drug Development, Neuss
Forschungszentrum Integrative Neurobiologie, Kiel
Wilhelm Sander-Stiftung, Neustadt/Donau
Varicella Zoster Virus Research Foundation, New York

Publications

Complete Publication List (PubMed)
2010
Korte J, Läubrich C, Fickenscher H, Rautenberg P (2010) Validation of a syndromic surveillance system of acute respiratory tract diseases in preschools of Schleswig-Holstein (SHARE). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 53, 917-924.
Maier T, Schwarting A, Mauer D, Ross RS, Martens A, Kliem V, Wahl J, Panning M, Baumgarte S, Müller T, Pfefferle S, Ebel H, Schmidt J, Tenner-Racz K, Racz P, Schmid M, Strüber M, Wolters B, Gotthardt D, Bitz F, Frisch L, Pfeiffer N, Fickenscher H, Sauer P, Rupprecht CE, Roggendorf M, Haverich A, Galle P, Hoyer J, Drosten C (2010) Management and outcomes after multiple corneal and solid organ transplantations from a donor infected with rabies virus. Clin. Infect. Dis. 50, 1112-1119.
Toptan T, Ensser A, Fickenscher H (2010) Rhadinovirus vector-derived human telomerase reverse transcriptase expression in primary T cells. Gene Ther. 17, 653-661.
Künzel S, Till A, Winkler M, Häsler R, Lipinski S, Jung S, Grötzinger J, Fickenscher H, Schreiber S, Rosenstiel P (2010) The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses. J. Immunol. 184, 1990-2000.
2009
Wussow F, Fickenscher H, Tischer BK (2009) Red-mediated transposition and final release of the mini-F vector of a cloned infectious herpesvirus genome. PLoS One 4, e8178.
Rautenberg P, Grancicova L, Hillenkamp J, Nölle B, Roider JB, Fickenscher H (2009) Acute retinal necrosis from the virologist's perspective. Ophthalmologe 106, 1065-1073.
Hillenkamp J, Nölle B, Rautenberg P, Fickenscher H, Roider J (2009) Acute retinal necrosis: Clinical features and therapy options. Ophthalmologe 106, 1058-1064.
Hillenkamp J, Nölle B, Bruns C, Rautenberg P, Fickenscher H, Roider J (2009) Acute retinal necrosis: clinical features, early vitrectomy, and outcomes. Ophthalmology 116, 1971-1975.
Warnke PH, Becker ST, Podschun R, Sivananthan S, Springer IN, Russo PA, Wiltfang J, Fickenscher H, Sherry E (2009) The battle against multi-resistant strains: Renaissance of antimicrobial essential oils as a promising force to fight hospital-acquired infections. J. Craniomaxillofac. Surg. 37, 392-397.
Schmidt M, Korn K, Nübling CM, Chudy M, Kress J, Horst HA, Geusendam G, Hennig H, Sireis W, Rabenau HF, Doerr HW, Berger A, Hourfar MK, Gubbe K, Karl A, Fickenscher H, Tischer BK, Babiel R, Seifried E, Gürtler L (2009) First transmission of human immunodeficiency virus Type 1 by a cellular blood product after mandatory nucleic acid screening in Germany. Transfusion 49, 1836-1844.
2008
Warnke PH, Becker ST, Springer IN, Haerle F, Ullmann U, Russo PA, Wiltfang J, Fickenscher H, Schubert S (2008) Penicillin compared with other advanced broad spectrum antibiotics regarding antibacterial activity against oral pathogens isolated from odontogenic abscesses. J. Craniomaxillofac. Surg. 36, 462-467.
Hasselbach HC, Fickenscher H, Nölle B, Roider J (2008) Atypical ocular toxoplasmosis with concomitant ocular reactivation of varicella-zoster virus and cytomegalovirus in an immunocompromised host. Klin. Monbl. Augenheilkd. 225, 236-239.
Warnke PH, Becker ST, Springer IN, Härle F, Ullmann U, Russo PA, Wiltfang J, Fickenscher H, Schubert S (2008) 'Grandmother penicillin' - not in vogue, but clinically still effective. J. Antimicrob. Chemother. 61, 960-962.
2007
Knorr B, Kessler U, Pöschl J, Fickenscher H, Linderkamp O (2007) A haemophagocytic lymphohistiocytosis (HLH)-like picture following breastmilk transmitted cytomegalovirus infection in a preterm infant. Scand. J. Infect. Dis. 39, 173-176.
Opelz G, Daniel V, Naujokat C, Fickenscher H, Döhler B (2007) Effect of cytomegalovirus prophylaxis with immunoglobulin or with antiviral drugs on post-transplant non-Hodgkin lymphoma: a multicentre retrospective analysis. Lancet Oncol. 8, 212-218.
2006
Braum O, Pirzer H, Fickenscher H (2006) Interleukin-26, an epitheliotropic T-cell cytokine. Curr. Med. Chem. Anti-Inflammatory and Anti-Allergy Agents 5, 275-277.
Collenberg E, Ouedraogo T, Ganame J, Fickenscher H, Kynast-Wolf G, Becher H, Kouyate B, Kräusslich HG, Sangare L, Tebit DM (2006) Seroprevalence of six different viruses among pregnant women and blood donors in rural and urban Burkina Faso: A comparative analysis. J. Med. Virol. 78, 683-692.
Eisenbach C, Longerich T, Fickenscher H, Schalasta G, Stremmel W, Encke J (2006) Recurrence of clinically significant hepatitis A following liver transplantation for fulminant hepatitis A. J. Clin. Virol. 35, 109-112.
2005
Fickenscher H, Fleckenstein B, Ensser A (2005) Pro- and anti-apoptotic strategies of viruses. In: Apoptosis in Health and Disease, Holcik M, Ed., Cambridge University Press, Cambridge, England. 
2004
Fickenscher H, Pirzer H (2004) Interleukin-26. Int. Immunopharm. 4, 609-613.
Fleckenstein B, Schmidt B, Korn K, Pauli G, Gürtler L, Kräusslich HG, Fickenscher H (2004) Humanes T-Zell-Leukämievirus, Typ 1 und 2. In: Diagnostik und Therapie der Viruskrankheiten, Mertens T, Haller O, Klenk HD, Eds., Urban & Fischer, München.
Fleckenstein B, Schmidt B, Walter H, Gürtler L, Kräusslich HG, Fickenscher H, Brockmeyer N, Überla K, Schüpbach J (2004) Humanes Immunschwächevirus, Typ 1 und 2. In: Diagnostik und Therapie der Viruskrankheiten, Mertens T, Haller O, Klenk HD, Hrsg., Urban & Fischer, München.
Hör S, Pirzer H, Dumoutier L, Bauer F, Wittmann S, Sticht H, Renauld JC, de Waal-Malefyt R, Fickenscher H (2004) The T-cell lymphokine IL-26 targets epithelial cells through IL-20R1 and IL-10R2 chains. J. Biol. Chem. 279, 33343-33351.
Loparev VN, Gonzales A, Deleon-Carnes M, Tipples G, Fickenscher H, Torfason EG, Schmid DS (2004) Global identification of three major genotypes of varicella-zoster virus: longitudinal clustering and strategies for genotyping. J. Virol. 78, 8349-8358.
Tamgüney G, van Snick J, Fickenscher H (2004) Autocrine stimulation of rhadinovirus-transformed T cells by the chemokine CCL1/I-309. Oncogene 23, 8475-8485.
2003
Dumoutier L, Lejeune D, Hör S, Fickenscher H, Renauld JC (2003) Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT) 1, STAT2 and STAT3. Biochem. J. 370, 391-396.
Ensser A, Thurau M, Wittmann S, Fickenscher H (2003) Genome of herpesvirus saimiri C488 which is capable of transforming human T cells. Virology 314, 471-487.
Fickenscher H, Fleckenstein B, Ensser A (2003) Pro- and anti-apoptotic strategies of viruses. In: Apoptosis in Health and Disease, Holcik M, Ed., Cambridge University Press, Cambridge, England, in press.
Schmidt M, Kress M, Heinemann S, Fickenscher H (2003) Varicella zoster virus isolates, but not the vaccine strain OKA, induce sensitivity to alpha-1 and beta-1 adrenergic stimulation of sensory neurones in culture. J. Med. Virol. 70S, 82-89.
2002
Ensser A, Neipel F, Fickenscher H (2002) Rhadinovirus pathogenesis. In: Structure-function relationships of human pathogenic viruses, Bogner E, Holzenburg A, Eds., Kluwer Press, London, 394-429.
Fickenscher H, Fleckenstein B (2002) Genus Rhadinovirus. In: Tidona CA, Darai G, Eds., The Springer Index of Viruses - a comprehensive encyclopedic reference, Springer-Verlag, 439-447.
Fickenscher H, Fleckenstein B (2002) Growth-transformation of human T cells. Meth. Microbiol. 32, 657-692.
Fickenscher H, Hör S, Küpers H, Knappe A, Wittmann S, Sticht H (2002) The Interleukin-10 cytokine family. Trends Immunol. 23, 89-96.
2001
Fickenscher H, Fleckenstein B (2001) Herpesvirus saimiri. In: Rickinson A, Weiss R, Epstein A (Eds.) Oncogenic gamma-herpesviruses: an expanding family. Philos. Trans. R. Soc. Lond. B 356, 545-567.
Fickenscher H, Korn K, Schmidt B (2001) Virale Immundefizienz: Epidemiologie - Diagnose - Therapie - Prophylaxe. Bayerisches Ärzteblatt 56, 163-166.
Goodwin DJ, Walters MS, Smith PG, Thurau M, Fickenscher H, Whitehouse A (2001) Herpesvirus saimiri open reading frame 50 (Rta) protein reactivates the lytic replication cycle in a persistently infected A549 cell line. J. Virol. 75, 4008-4013.
Greve T, Tamgüney G, Fleischer B, Fickenscher H, Bröker B (2001) Downregulation of p56Lck tyrosine kinase activity in T cells of squirrel monkeys (Saimiri sciureus) correlates with the non-transforming and apathogenic properties of herpesvirus saimiri in its natural host. J. Virol., 75, 9252-9261.
Hör S, Küpers H, Fickenscher H (2001) AK155. In: Oppenheim J, Feldmann M (Eds.) Cytokine reference, Academic press, London.
Kress M, Fickenscher H (2001) Infection by human varicella zoster virus confers norepinephrine sensitivity to sensory neurons from rat dorsal root ganglia. FASEB-J. 15, 1037-1043.
2000
Hiller C, Wittmann S, Slavin S, Fickenscher H (2000a) Functional long-term thymidine kinase suicide gene expression in human T cells using a herpesvirus saimiri vector. Gene Ther. 7, 664-674.
Hiller C, Tamgüney G, Stolte N, Mätz-Rensing K, Lorenzen D, Hör S, Thurau M, Wittmann S, Slavin S, Fickenscher H (2000b) Herpesvirus saimiri pathogenicity enhanced by thymidine kinase of herpes simplex virus. Virology 278, 445-455.
Knappe A, Hör S, Wittmann S, Fickenscher H (2000) Induction of a novel cellular homolog to interleukin-10, AK155, by transformation of T lymphocytes with Herpesvirus saimiri. J. Virol. 74, 3881-3887.
Knappe A, Feldmann G, Dittmer U, Meinl E, Nisslein T, Wittmann S, Kirchner T, Mätz-Rensing K, Bodemer W, Fickenscher H (2000) Herpesvirus saimiri-transformed macaque T cells are tolerated and do not cause lymphoma after autologous reinfusion. Blood 95, 3256-3261.
Meinl E, Fickenscher H (2000) Viral transformation of lymphocytes. In: Rowland-Jones S, McMichael A (Eds.) Lymphocytes - A practical approach, IRL/OUP, Oxford, p. 55-74.
Meinl E, Fickenscher H (2000) Commonly used human lymphoma lines. In: Rowland-Jones S, McMichael A (Eds.) Lymphocytes - A practical approach, IRL/OUP, Oxford, p. 338-341.
Thurau M, Whitehouse A, Wittmann S, Meredith D, Fickenscher H (2000) Distinct transcriptional and functional properties of the R transactivator gene, orf50, of the transforming herpesvirus saimiri strain C488. Virology 268, 167-177.
1999
Bröker BM, Fickenscher H (1999) Herpesvirus saimiri strategies for T cell stimulation and transformation. Med. Microbiol. Immunol. 187, 127-136.
Vella C, Zheng NN, Vella G, Atkins C, Bristow RGW, Fickenscher H, Daniels RS (1999) Enhanced replication of M-tropic HIV-1 strains in herpesvirus saimiri immortalised T-cells which express CCR5. J. Virol. Meth. 79, 51-63.
Vella C, King D, Zheng NN, Fickenscher H, Breuer J, Daniels RS (1999) Alterations in the V1/V2 domain of HIV-2 CBL24 gp105 correlate with an extended cell tropism. AIDS Res. Hum. Retroviruses 15, 1399-1402.
1998
Bauer M, Lucchiari-Hartz M, Fickenscher H, Eichmann K, McKeating J, Meyerhans A (1998) Herpesvirus saimiri-transformed human CD4+ T cell lines: An efficient target cell system for the analysis of human immunodeficiency virus-specific CTL activity. J. Virol. 72, 1627-1631.
Derfuss T, Fickenscher H, Kraft M, Henning G, Lengenfelder D, Fleckenstein B, Meinl E (1998) Anti-apoptotic activity of the herpesvirus saimiri encoded Bcl-2 homolog: Stabilization of mitochondria and inhibition of caspase-3 like activity. J. Virol. 72, 5897-5904.
Fickenscher H, Fleckenstein B (1998) Growth-transformation of human T cells. Meth. Microbiol. 25, 573-602.
Knappe A, Thurau M, Niphuis H, Hiller C, Wittmann S, Kuhn EM, Rosenwirth B, Fleckenstein B, Heeney J, Fickenscher H (1998) T-cell lymphoma caused by herpesvirus saimiri C488 independently of ie14/vsag, a viral gene with superantigen-homology. J. Virol. 72, 3469-3471.
Knappe A, Hiller C, Niphuis H, Fossiez F, Thurau M, Wittmann S, Kuhn, EM, Lebecque S, Banchereau J, Rosenwirth B, Fleckenstein B, Heeney J, Fickenscher H (1998) The interleukin-17 gene of herpesvirus saimiri. J. Virol. 72, 5797-5801.
Kraft M, Henning G, Fickenscher H, Lengenfelder D, Tschopp J, Fleckenstein B, Meinl E (1998) Herpesvirus saimiri transforms human T cell clones to stable growth without inducing resistance to apoptosis. J. Virol. 72, 3138-3145.
Meinl E, Fickenscher H, Thome M, Tschopp J, Fleckenstein B (1998) Anti-apoptotic strategies of lymphotropic viruses. Immunol. Today 19, 474-479.
1997
Fickenscher H, Bökel C, Knappe A, Biesinger B, Meinl E, Fleischer B, Fleckenstein B, Bröker B (1997) Functional phenotype of transformed human alpha beta and gamma delta T cells determined by different subgroup C strains of herpesvirus saimiri. J. Virol. 71, 2252-2263.
Meinl E, Fickenscher H, Hoch R, de Waal Malefyt R, 't Hart B, Wekerle H, Hohlfeld R, Fleckenstein B (1997) Growth transformation of antigen-specific T cell lines from rhesus monkeys by herpesvirus saimiri. Virology 229, 175-182.
Feldmann G, Fickenscher H, Bodemer W, Spring M, Nisslein T, Hunsmann G, Dittmer U (1997) Generation of herpesvirus saimiri-transformed T-cell lines from macaques is restricted by reactivation of simian spumaviruses. Virology 229, 106-112.
Thome M, Schneider P, Hofmann K, Fickenscher H, Meinl E, Neipel F, Mattmann C, Burns K, Bodmer J, Schröter M, Scaffidi C, Krammer PH, Peter M, Tschopp J (1997) Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 386, 517-521.
Vella C, Fickenscher H, Atkins C, Penny M, Daniels R (1997) Herpesvirus saimiri immortalized human T-cells support long term, high titred replication of HIV-1/2. J. Gen. Virol. 78, 1405-1409.
Knappe A, Hiller C, Thurau M, Wittmann S, Hofmann H, Fleckenstein B, Fickenscher H (1997) The superantigen-homologous viral immediate-early gene ie14/vsag in herpesvirus saimiri-transformed human T cells. J. Virol. 71, 9124-9133.
1996
Fickenscher H, Biesinger B, Knappe A, Wittmann S, Fleckenstein B (1996) Regulation of the herpesvirus saimiri oncogene stpC similar to that of T cell activation genes in growth-transformed human T lymphocytes. J. Virol. 70, 6012-6019.
Fickenscher H, Meinl E, Knappe A, Wittmann S, Fleckenstein B (1996) TCR expression of herpesvirus saimiri immortalized human T cells. Immunologist 4, 41-43.
Klein J, Fickenscher H, Holliday J, Biesinger B, Fleckenstein B (1996) Herpesvirus saimiri immortalized gamma delta T cell line activated by IL-12. J. Immunol. 156, 2754-2760.
Kretschmer C, Murphy C, Biesinger B, Beckers J, Fickenscher H, Kirchner T, Fleckenstein B, Rüther U (1996) A herpes saimiri oncogene causes peripheral T-cell lymphoma in transgenic mice. Oncogene 12, 1609-1616.
Meinl E, Fickenscher H, Fleckenstein B (1996) Chemokine receptors and chemokine inducing molecules of lymphotropic herpesviruses. Immunol. Today 17, 199.
1995
Biesinger B, Tsygankov A, Fickenscher H, Emmrich F, Fleckenstein B, Bolen J, Bröker B (1995) The product of the herpesvirus saimiri open reading frame 1 (Tip) interacts with T cell-specific kinase p56lck in transformed cells. J. Biol. Chem. 270, 4729-4734.
Meinl E, 't Hart B, Bontrop R, Hoch R, Iglesias A, de Waal Malefyt R, Fickenscher H, Müller-Fleckenstein I, Fleckenstein B, Wekerle H, Hohlfeld R, Jonker M (1995) Activation of a myelin basic protein-specific human T cell clone by antigen-presenting cells from rhesus monkeys. Int. Immunol. 7, 1489-1495.
Poleev A, Wendler F, Fickenscher H, Zannini M, Yaginuma K, Abbott C, Plachov D (1995) Distinct functional properties of three human paired- box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors. Eur. J. Biochem. 228, 899-911.
1994
Bröker B, Tsygankov A, Fickenscher H, Chitaev N, Schulze-Koops H, Müller-Fleckenstein I, Fleckenstein B, Bolen J, Emmrich F (1994) Engagement of the CD4 receptor inhibits the Interleukin-2 dependent proliferation of human T cells transformed by herpesvirus saimiri. Eur. J. Immunol. 24, 843-850.
Del Prete G, De Carli M, D'Elios M, Müller-Fleckenstein I, Fickenscher H, Fleckenstein B, Almerigogna F, Romagnani S (1994) Polyclonal B cell activation induced by herpesvirus saimiri-transformed human CD4+ T cell clones: Role for membrane TNF-alpha/TNF-alpha receptors and CD2/CD58 interactions. J. Immunol. 153, 4872-4879.
Fickenscher H, Fleckenstein B (1994) Generation of human T cell lines using lymphotropic herpesviruses. In: Methods in molecular genetics, Volume 4, Molecular virology techniques part A, Adolph K, Ed., Academic Press San Diego, 345-362.
Huppes W, Fickenscher H, 't Hart B, Fleckenstein B (1994) Cytokine dependence of human to mouse graft versus host disease. Scand. J. Immunol. 40, 26-36.
Troidl B, Simmer B, Fickenscher H, Müller-Fleckenstein I, Emmrich F, Fleckenstein B, Gebhart E (1994) Karyotypic characterization of human T cell lines immortalized by herpesvirus saimiri. Int. J. Cancer 56, 433-438.
1993
De Carli M, Berthold S, Fickenscher H, Müller-Fleckenstein I, D'Elios M, Gao Q, Biagiotti R, Giudizi M, Kalden JR, Fleckenstein B, Romagnani S, Del Prete G (1993) Immortalization with herpesvirus saimiri modulates the cytokine secretion profile of established Th1 and Th2 human T cell clones. J. Immunol. 151, 5022-5030.
Fickenscher H, Chalepakis G, Gruss P (1993) Murine Pax-2 protein is a sequence specific transactivator with expression in the genital system. DNA Cell Biol. 12, 381-391.
Fickenscher H, Grassmann R, Biesinger B, Ramstedt U, Haseltine W, Desrosiers R, Fleckenstein B (1993) Viral genes involved in stable growth transformation of human T-lymphocytes. In: Virus strategies: Molecular biology and pathogenesis, Doerfler W, Böhm P, Eds., VCH Verlag Chemie Weinheim New York, 401-406.
Nick S, Fickenscher H, Biesinger B, Born G, Jahn G, Fleckenstein B (1993) Herpesvirus saimiri transformed human T cell lines - a permissive system for human immunodeficiency viruses. Virology 194, 875-877.
Weber F, Meinl E, Drexler K, Czlonkowska A, Huber S, Fickenscher H, Müller-Fleckenstein I, Fleckenstein B, Wekerle H, Hohlfeld R (1993) Herpesvirus saimiri-transformed human T cell lines expressing functional receptor for myelin basic protein. Proc. Natl. Acad. Sci. USA 90, 11049-54.
1992
Chowdhury K, Goulding M, Walther C, Imai K, Fickenscher H (1992) The ubiquitous transactivator Zfp-38 is upregulated during spermatogenesis with differential transcription. Mech. Dev. 39, 129-142.
Lang D, Fickenscher H, Stamminger T (1992) Analysis of proteins binding to the proximal promoter region of the human cytomegalovirus IE-1/2 enhancer/promoter reveals both consensus and aberrant recognition sequences for transcription factors SP1 and CREB. Nucl. Acids Res. 20, 3287-3295.
Poleev A, Fickenscher H, Mundlos S, Winterpacht A, Zabel B, Fidler A, Gruss P, Plachov D (1992) PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors. Development 116, 611-623.
1991
Chalepakis G, Fritsch R, Fickenscher H, Deutsch U, Goulding M, Gruss P (1991) The molecular basis of the undulated/Pax-1 mutation. Cell 66, 873-884.
1990
Stamminger T, Fickenscher H, Fleckenstein B (1990) Cell type-specific induction of the major immediate early enhancer of human cytomegalovirus by cyclic AMP. J. Gen. Virol. 71, 105-113.
1989
Fickenscher H, Stamminger T, Rüger R, Fleckenstein B (1989) The role of a repetitive palindromic sequence element in the human cytomegalovirus major immediate early enhancer. J. Gen. Virol. 70, 107-123.